The use of amantadine in medicine and COVID-19
Amantadine hydrochloride and other amantadine derivatives are the only drugs available (so far) that directly affect the inactivation of SARS-CoV-2 virus, possibly changing its development environment from acid to alkaline. And they also potentially have many other mechanisms of action, including possibly unexplored. (1,2,3)
Amantadine has many uses today. Analyzing all the studies in the field of neurology about the effects of amantadine on the nervous system in such diseases as: strokes, brain injuries or severe brain damage – amantadine is the most effective. It is used in neurological departments because it regenerates brain cells. According to the research, 89% of patients using amantadine improved their health, including 54% who improved significantly. (4,5,6,7) It also reduces swelling and inflammation, and studies of amantadine side effects are compared to the placebo level – so they are close to zero. (4.6)
From my own observations – in patients with COVID-19 – treatment with amantadine causes the regression of inflammatory changes and regeneration in the lungs. It is much better and faster than in patients not treated with amantadine. All treatment is significantly shortened. For example, when comparing hospital patients who took amantadine on their own responsibility to patients who did not take it, they left hospital faster, often much better on discharge (patient data available for review).
Some patients with COVID-19 and not treated with amantadine, develop auscultation changes in the lungs even after several weeks. Administration of antibiotics with amantadine even after this time gives very good therapeutic effects (medical data available for review).
Recent English publications show that 78% of people have developed myocarditis after more than 2 months after contracting COVID-19. As many as 60% showed that they still had active myocarditis. Regardless of whether they were treated at home or in the hospital. (8,9,10)
From my own observation I can say that patients who received amantadine, the process of their convalescence and increase of tolerance to exercise is faster. After all, I do not recommend excessive exercise for 2-3 months. Also, based on personal experience and observation, patients receiving amantadine have reduced pain symptoms in the chest.
I am not a clinician to describe the mechanisms of action of amantadine. I mentioned earlier that it probably has a few more snap points in the cells, some of which we probably don’t know yet. Some of the answers may already be provided by neurology today.
My conclusions are that amantadine is as effective on other cells as it does on the nervous system. It reduces inflammation and swelling in cells (e.g. pulmonary or cardiac), increases regeneration and limits their reactivity, which can significantly reduce or alleviate the number of complications after COVID-19.
Amantadine is a drug very effective in the treatment of COVID-19 and at the same time it works in reducing damage in many organs. I call for research and immediate enrollment of amantadine in COVID-19 treatment regimens as the main and only causal drug (so far) that acts directly on the SARS-CoV-2 virus, and at the same time is an extremely useful drug for symptomatic treatment.
Once again, we remind you that you cannot treat COVID-19 disease yourself with amantadine hydrochloride. In addition to treatment with amantadine, it is essential to treat any symptoms with other symptomatic medications after examination and medical supervision
- Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers – https://www.nature.com/articles/s41594-020-00536-8
- Amantadine Treatment for People with COVID-19 – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290190/
- Amantadine as a drug to mitigate the effects of COVID-19 https://www.sciencedirect.com/science/article/abs/pii/S030698772030654X
- Placebo-Controlled Trial of Amantadine for Severe Traumatic Brain Injury – https://www.nejm.org/doi/full/10.1056/nejmoa1102609
- Amantadine sulfate infusion in the treatment of vigilance and drive disorders – https://www.researchgate.net/publication/289604840_Amantadine_sulfate_infusion_in_the_treatment_of_vigilance_and_drive_disorders
- Long-term Health Consequences of COVID-19 – https://jamanetwork.com/journals/jama/fullarticle/2771581
- Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) – https://pubmed.ncbi.nlm.nih.gov/32730619/